The journey to 100 friends begins with a single conversation. Socially anxious high school student Shoko Komi's greatest dream is to make some friends, but everyone at school mistakes her crippling social anxiety for cool reserve. Luckily she meets Tadano, a timid wallflower who decides to step out of his comfort zone in order to help her achieve her goal of making 100 friends.

Komi is in her final year of high school, and that means she's running out of time to achieve her goal of making 100 friends! She starts off strong on the first day of classes, but a cynical new classmate's bitter outlook soon sparks a school-wide battle royale. Can Komi make a new ally in the trenches, or will pessimism win the day?